BY KATHERINE HIGHNETT: A “ground-breaking” trial of a type 1 diabetes drug that could help reduce the life-altering complications of the disease has begun in Cardiff, U.K.
The first two patients in the world have been given an investigational drug that could regrow crucial hormone-producing cells, researchers have reported. If successful, the drug may reduce patients’ reliance on daily injections. (read more)
BY SCIENCE DAILY: Mothers with elevated blood glucose during pregnancy — even if not high enough to meet the traditional definition of gestational diabetes — were significantly more likely to have developed type 2 diabetes a decade after pregnancy than their counterparts without high blood glucose.
For children born to mothers with elevated or normal glucose, researchers found no statistically significant difference between the two groups of children in terms of their combined overweight and obesity, the study’s primary outcome. However, when obesity was measured alone, children of mothers with elevated blood glucose were significantly more likely to be obese. (read more)
BY MEDICAL EXPRESS: The main cause of all forms of diabetes is pancreatic beta-cell dysfunction. Beta cells, found in the pancreatic islets, store and release insulin. Decades of research with animal and cellular models have expanded the knowledge on the molecular mechanisms causing the beta-cells to dysfunction. Diego Balboa’s doctoral research now offers a more precise model that employs human pluripotent stem cells.
“Human pluripotent stem cells constitute a renewable source of beta-cells. Stem cell-derived beta-cells can be generated by directed differentiation and used as a model to study pancreatic beta-cell development and disease in vitro,” Balboa explains. (read more)
BY EMMA COURT: About two months ago, grad student Azure Grant began wearing a glucose monitor every day.
These devices track glucose, also called blood sugar, which comes from food and which the body subsequently uses for fuel. Diabetics have trouble regulating their glucose levels, and thus must track them closely.
Here’s the catch: Grant doesn’t have diabetes. But she began to be more curious about glucose after working with a group of diabetic individuals. She wondered: how reliably can it be measured? How did it change over time? What factors affect it, and what might it have to say about human health? (read more)
BY JENNIFER BYRNE: In adults with type 2 diabetes, sleep quality scales can serve as useful tools for predicting obstructive sleep apnea, with similar predictive values observed across various questionnaires, according to findings published in the Journal of Diabetes.
“The risk of developing diabetes associated with sleep disturbances has been found to be comparable to that of other traditional risk factors as obesity, family history and physical inactivity. It has been suggested that sleep disturbances should be considered in the clinical guidelines for type 2 diabetes screening,” Athanasia Pataka, MD, of the respiratory failure unit at G Papanikolaou Hospital, Thessaloniki, Greece, and colleagues wrote in the study background. “Thus, a systematic screening for [obstructive sleep apnea] in patients with [type 2 diabetes] with easy-to-use and accurate screening tools is warranted.” (read more)