BY CATHARINE PADDOCK: Researchers at the Stanford University School of Medicine as well as the Veteran Affairs Palo Alto Health Care System, both in California, have led an investigation that linked genetic information on 300,000 veterans to their electronic health records.
It focused on three gene variants, or mutations, that change the way their associated genes behave.
Studies of gene mutations usually uncover how they damage health or give rise to disease, but in this study, the gene variants are all linked to positive effects. (read more)
BY KATRINA TURRILL: Type 2 diabetes is a condition where the body doesn’t produce enough insulin, which regulates how the body uses and stores glucose and fat. It helps the body’s cells takes glucose from the blood which it then turns into energy.
A common condition in the UK, this type of diabetes is often caused by a person being overweight or obese.
Many people with type 2 diabetes don’t realise they have it because symptoms don’t necessarily make you feel unwell. But if it’s left untreated, it can lead to serious complications.
One warning sign to watch out for is drinking a lot of water, but how much is a lot of water? (read more)
BY IANS: Middle-aged with diabetes are at greater risk of developing arthritis and osteoporosis, in addition to increased risk to the heart, a study has found.
Researchers from the Nordsjaellands University Hospital in Denmark have found that people with diabetes are 33 per cent more likely to suffer from osteoarthritis — a type of arthritis that occurs when flexible tissues at the ends of bones wear down. (read more)
BY NEWS-MEDICAL: Researchers at St Vincent’s Institute in Melbourne have identified a key target of the immune response that causes type 1 diabetes.
Type 1 diabetes is an incurable autoimmune disease caused by the destruction of insulin-producing beta cells in the pancreas by immune cells called T cells. A specific type of T cell, a CD4+ T cell, recognizes a part of the beta cell (called an antigen) as foreign, initiating the immune response. Researchers have long been searching for the identity of the antigen that drives the disease.
Earlier work from A/Prof Mannering’s group showed that CD4+ T cells in the pancreas of an organ donor who hadtype 1 diabetes responded to a specific part of insulin’s precursor, proinsulin, known as C-peptide. (read more)
BY MEDICAL XPRESS: At the 2018 Meeting of the European Association for the Study of Diabetes, Brigham and Women’s Hospital investigators from the Thrombolysis in Myocardial Infarction (TIMI) Study Group presented diabetes-related findings from CAMELLIA-TIMI 61, a clinical trial of overweight and obese patients designed to test lorcaserin, a weight loss drug manufactured by the trial’s sponsor, Eisai Inc. In addition to reporting sustained weight loss without an increased risk of major cardiovascular events, the TIMI Study Group also presented data showing that lorcaserin reduced the risk of diabetes by 19 percent in patients with pre-diabetes, induced remission of hyperglycemia in patients with diabetes, and reduced the risk of diabetic microvascular complications such as microalbuminuria. The team’s findings are detailed in a paper published simultaneously in The Lancet. (read more)